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A smartphone-integrated Pt@Cu-HCF nanozyme-based paper sensor for on-site determination of total antioxidant capacity in marine oils.

Mengqi Yu·Hong Chen·Yuyang Zhang·Shutong Zhang·Jiao Li·Jianan Sun·Sai Wang·Xiangzhao Mao
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Abstract

Total antioxidant capacity (TAC) serves as a key indicator for evaluating the nutritional quality of foods. In this study, we designed a platinum-embedded copper hexacyanoferrate (denoted as Pt@Cu-HCF) nanozyme that exhibits high oxidase-like activity, efficiently catalyzing the oxidation of chromogenic substrates to generate robust colorimetric signals. Antioxidants quench hydroxyl radicals (∙OH) produced during the catalytic process, leading to a concentration-dependent suppression of the color signal. Leveraging this mechanism, a smartphone-integrated, colorimetric paper sensor for on-site TAC quantification was developed, using vitamin E as the calibration standard. The sensor was applied to determine TAC in fish oil, algal oil, and krill oil, demonstrating a linear response range of 9.78-312.5 μM and a limit of detection (LOD) of 6.41 μM. Validation using real-world marine oil samples showed excellent agreement with a commercial assay kit, confirming the reliability and practical applicability of this portable sensor for TAC measurement in complex biological matrices.

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AntioxidantsPlatinumColorimetryLimit of DetectionCopperSmartphoneReproducibility of ResultsPaperFerrocyanidesAnimalsOxidation-ReductionFish OilsOilsMarine oilNanozymePaper-based sensorTotal antioxidant capacityJournal Article

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Mengqi Yu, Hong Chen, Yuyang Zhang, Shutong Zhang, Jiao Li, Jianan Sun, Sai Wang, Xiangzhao Mao. 2026-07-14. A smartphone-integrated Pt@Cu-HCF nanozyme-based paper sensor for on-site determination of total antioxidant capacity in marine oils.. https://doi.org/10.1016/j.foodres.2026.120026

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Journal Article resourceAnimals subjectAntioxidants subjectColorimetry subjectJournal Article subjectLimit of Detection subjectOxidation-Reduction subject

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