Generation and characterization of two iPSC lines INDBi002-A and INDBi002-B from human keratinocytes of a healthy female using Sendai Virus reprogramming.

Denise Sperlich; Katharina Becker; Stefanie Klingenstein; Ulrike Mau-Holzmann; Stefan Liebau; Kevin Achberger

doi:10.1016/j.scr.2026.104075

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Generation and characterization of two iPSC lines INDBi002-A and INDBi002-B from human keratinocytes of a healthy female using Sendai Virus reprogramming.

Denise Sperlich·Katharina Becker·Stefanie Klingenstein·Ulrike Mau-Holzmann·Stefan Liebau·Kevin Achberger

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Abstract

We established two fully characterized induced pluripotent stem cell (iPSC) lines from human keratinocytes via Sendai virus-mediated reprogramming. This non-integrating approach maintains genomic integrity, facilitating the generation of pluripotent cell lines with stable self-renewal and multilineage differentiation potential. Characterization confirmed the expression of stemness markers, the capacity for trilineage differentiation, and a normal karyotype. The iPSC lines are a valuable platform for applications in disease modeling, pharmacological screening, and regenerative medicine.

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Humans Induced Pluripotent Stem Cells Female Keratinocytes Sendai virus Cellular Reprogramming Cell Differentiation Cell Line Journal Article

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Denise Sperlich, Katharina Becker, Stefanie Klingenstein, Ulrike Mau-Holzmann, Stefan Liebau, Kevin Achberger. 2026-08-11. Generation and characterization of two iPSC lines INDBi002-A and INDBi002-B from human keratinocytes of a healthy female using Sendai Virus reprogramming.. https://doi.org/10.1016/j.scr.2026.104075

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