Ulrike Mau-Holzmann | Search PubMed

PubMed2026

Generation and characterization of two iPSC lines INDBi002-A and INDBi002-B from human keratinocytes of a healthy female using Sendai Virus reprogramming.

We established two fully characterized induced pluripotent stem cell (iPSC) lines from human keratinocytes via Sendai virus-mediated reprogramming. This non-integrating approach maintains genomic integrity, facilitating the generation of pluripotent cell lines with stable self-renewal and multilineage differentiation potential. Characterization confirmed the expression of stemness markers, the capacity for trilineage differentiation, and a normal karyotype. The iPSC lines are a valuable platform for applications in disease modeling, pharmacological screening, and regenerative medicine.

Humans↗

PubMed2006

[Predictive diagnostics in chorea huntington: psychotherapeutic implications for counselling].

The progress in molecular genetic research leads to an increased availability of predictive diagnosis of inherited diseases. However, the prediction of an incurable illness is inevitably related with severe psychic conflicts. Based on the relevant literature, the psychological implications of predictive diagnostics are outlined, and counselling strategies for persons vulnerable for an inherited disease are summarized. In spite of numerous studies with persons at risk the prediction of the individual reaction remains rather difficult. Unconscious expectations play an essential, but underestimated role for the test motivation and coping strategies. Relieving the pressure of time supposed by most of the risk persons seems necessary to allow a deeper understanding of motivation and development of sound coping strategies. After disclosure of the test result, an ongoing counselling should be offered to all family members.

Adaptation, Psychological↗