Oliceridine used for patient-controlled analgesia on postoperative quality of recovery in patients undergoing laparoscopic gynecological tumour resection: a randomized clinical trial.

Chunyan Li; Xinna Luo; Yanli Du; Jinrui Wei; Yan Qiu; Wanyun Ge; Fei Lin

doi:10.1080/07853890.2026.2714613

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Oliceridine used for patient-controlled analgesia on postoperative quality of recovery in patients undergoing laparoscopic gynecological tumour resection: a randomized clinical trial.

Chunyan Li·Xinna Luo·Yanli Du·Jinrui Wei·Yan Qiu·Wanyun Ge·Fei Lin

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Abstract

BACKGROUND: Oliceridine, a novel biased μ-opioid receptor agonist, is widely used perioperatively, yet limited data exists regarding its impact on postoperative quality of recovery. This study investigated the effect of oliceridine-based patient-controlled intravenous analgesia (PCIA) on postoperative quality of recovery among patients undergoing laparoscopic gynecological tumour resection. METHODS: Ninety‑four female patients scheduled for elective laparoscopic gynecological tumour resection were included. Patients were randomized to two groups: oliceridine group (loading dose 1.5 mg, PCIA 0.55 mg/kg) or sufentanil group (loading dose 10 μg, PCIA 3 μg/kg). The primary outcome was the Quality of Recovery-40 (QoR-40) score on postoperative day 1. The secondary outcomes included the QoR-40 score, the numeric rating scale (NRS) pain score, the Hospital Anxiety and Depression Scale-Anxiety (HADS-A) score, the Fatigue, Resistance, Ambulation, Illness and Loss of weight (FRAIL) index and adverse events within 3 postoperative days. RESULTS: Higher QoR-40 scores were found in the oliceridine group on postoperative day 1 (182.9 ± 3.1 versus 177.5 ± 3.9, p < 0.001). Compared with the sufentanil group, the oliceridine group showed better QoR-40 scores within 3 days after operation. No significant differences were observed in NRS pain scores or HADS-A scores between the two groups (all p > 0.05). However, the median FRAIL score in the oliceridine group was lower on postoperative day 2 (p = 0.018). CONCLUSION: Oliceridine used in PCIA improves early postoperative recovery quality of patients undergoing laparoscopic gynecological tumour resection. It provides analgesic effect comparable to sufentanil and lowers incidences of postoperative frailty, nausea and vomiting. TRIAL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR.org.cn, identifier: ChiCTR2400094271.

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Chunyan Li, Xinna Luo, Yanli Du, Jinrui Wei, Yan Qiu, Wanyun Ge, Fei Lin. 2026-08-12. Oliceridine used for patient-controlled analgesia on postoperative quality of recovery in patients undergoing laparoscopic gynecological tumour resection: a randomized clinical trial.. https://doi.org/10.1080/07853890.2026.2714613

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Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't resource Adult subject Aged subject Analgesia, Patient-Controlled subject Analgesics, Opioid subject Enhanced recovery after surgery subject Female subject Genital Neoplasms, Female subject Gynecologic Surgical Procedures subject Humans subject Journal Article subject Laparoscopy subject Middle Aged subject Oliceridine subject Pain Measurement subject Randomized controlled trials study

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