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Effect of different liposomal bupivacaine concentrations in ultrasound-guided superior trunk block on postoperative analgesia and mobility: a randomized double-blind controlled trial protocol for shoulder arthroscopy.

Yu Zhou·Hong-Zhang Ding·Xiao-Qian Li·Teng Zheng·Mao-Lin Ran·Ai-Ling Song·Yi-Min Qiu·Jin-Bao Li·Feng Chen
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Abstract

BACKGROUND: Shoulder arthroscopy frequently causes severe postoperative pain that may impede recovery. Liposomal bupivacaine provides prolonged analgesia, and ultrasound-guided superior trunk block (STB) offers comparable analgesia to interscalene block with a lower risk of hemidiaphragmatic paralysis. However, the optimal concentration of liposomal bupivacaine for STB remains unknown. METHODS: This randomized, double-blind, controlled trial will enrol 282 adult patients scheduled for elective arthroscopic rotator cuff repair. Patients will be randomly allocated (1:1:1) to receive ultrasound-guided STB with liposomal bupivacaine 66 mg (Group A), 44 mg (Group B) or 33 mg (Group C), each diluted to 10 mL. The co-primary outcomes are (1) rest pain Numeric Rating Scale (NRS) score at 48 h post-surgery and (2) cumulative oral morphine milligram equivalents (MME) consumption within 0-48 h after surgery. Secondary outcomes include rest pain NRS scores at 6, 24 and 72 h; motor function assessed by Muscle Balance Scale, Bromage score and American Shoulder and Elbow Surgeons (ASES) score at 6, 24, 48 and 72 h; and Quality of Recovery-15 (QoR-15) score at 24 and 48 h. DISCUSSION: This study will provide evidence on the optimal concentration of liposomal bupivacaine for STB in arthroscopic shoulder surgery, aiming to achieve effective and prolonged analgesia without compromising shoulder mobility.

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HumansBupivacaineDouble-Blind MethodPostoperative PainArthroscopyAnesthetics, LocalLiposomesFemaleAdultUltrasonography, InterventionalNerve BlockMiddle AgedPain MeasurementRotator CuffMaleShoulder JointTreatment OutcomeLiposomal bupivacainepostoperative painprotocolshoulder arthroscopysuperior trunk blockJournal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov't

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Yu Zhou, Hong-Zhang Ding, Xiao-Qian Li, Teng Zheng, Mao-Lin Ran, Ai-Ling Song, Yi-Min Qiu, Jin-Bao Li, Feng Chen. 2026-06-23. Effect of different liposomal bupivacaine concentrations in ultrasound-guided superior trunk block on postoperative analgesia and mobility: a randomized double-blind controlled trial protocol for shoulder arthroscopy.. https://doi.org/10.1080/07853890.2026.2685345

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Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't resourceAdult subjectAnesthetics, Local subjectArthroscopy subjectBupivacaine subjectDouble-Blind Method subjectFemale subjectHumans subjectJournal Article subjectLiposomal bupivacaine subjectLiposomes subjectMale subjectMiddle Aged subjectNerve Block subjectPain Measurement subjectRandomized controlled trials study

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