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PubMed · 42503495

Efficacy of CagriSema for Reaching Anthropometric Treatment Targets and Cardiometabolic Outcomes: A Secondary, Post hoc Analysis of REDEFINE 1.

Luca Busetto·Cynthia Osorto Contreras·Mikkel Hovden Christensen·Timothy W Garvey·Deborah B Horn·Barbara McGowan·Claire Prener Miller·Volker Schnecke·Carel W le Roux
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Abstract

AIMS: To assess the added value of absolute anthropometric targets alongside percentage weight loss in the clinical management of obesity. MATERIALS AND METHODS: The phase 3a, 68-week REDEFINE 1 trial randomised adults without diabetes with BMI &#x2265;&#x2009;30&#x2009;kg/m2, or&#x2009;&#x2265;&#x2009;27&#x2009;kg/m2 with &#x2265;&#x2009;1 obesity-related complication, to once-weekly CagriSema 2.4&#x2009;mg/2.4&#x2009;mg, semaglutide 2.4&#x2009;mg, cagrilintide 2.4&#x2009;mg, or placebo, plus lifestyle intervention. This secondary, post hoc analysis assessed the proportions of participants achieving BMI <&#x2009;27&#x2009;kg/m2 and/or WHtR <&#x2009;0.53 targets, and percentage weight loss by anthropometric target. The association between the proportion of participants maintaining or achieving normalisation of four cardiometabolic outcomes: normoglycemia (glycated haemoglobin <&#x2009;5.7% and fasting plasma glucose <&#x2009;5.6&#x2009;mmol/L); blood pressure (<&#x2009;130/80&#x2009;mmHg); triglycerides (<&#x2009;1.7&#x2009;mmol/L); lipids (high-density lipoprotein cholesterol &#x2265;&#x2009;1.3&#x2009;mmol/L [female] or &#x2265;&#x2009;1.0&#x2009;mmol/L [male]) and reaching anthropometric targets or change in body weight (%) was also assessed. RESULTS: The proportion of participants achieving both BMI <&#x2009;27&#x2009;kg/m2 and WHtR <&#x2009;0.53 targets at week 68 was 30.3%, 19.1%, 9.0%, and 3.3% in participants who received CagriSema, semaglutide, cagrilintide, or placebo respectively. Both BMI and WHtR performed similarly as indicators for all four cardiometabolic outcomes. At more stringent cut-off values, anthropometric targets were better measures than percentage weight loss. CONCLUSIONS: The proportion of participants achieving anthropometric targets was greater with CagriSema Versus other treatments. These findings support further validation of BMI and WHtR anthropometric treatment targets and indicate a potential for indicating amelioration of clinical outcomes in obesity and a greater emphasis on target-based treatment strategies.

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HumansFemaleObesitySemaglutideMaleWeight LossMiddle AgedBody Mass IndexGlucagon-Like PeptidesTreatment OutcomeBlood GlucoseAdultAnti-Obesity AgentsBlood PressureDouble-Blind MethodGlycated HemoglobinTriglyceridesclinical trialobesity careobesity therapyweight managementJournal ArticleRandomized Controlled Trial

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Luca Busetto, Cynthia Osorto Contreras, Mikkel Hovden Christensen, Timothy W Garvey, Deborah B Horn, Barbara McGowan, Claire Prener Miller, Volker Schnecke, Carel W le Roux. 2026-07-26. Efficacy of CagriSema for Reaching Anthropometric Treatment Targets and Cardiometabolic Outcomes: A Secondary, Post hoc Analysis of REDEFINE 1.. https://doi.org/10.1111/dom.71134

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Journal Article; Randomized Controlled Trial resourceAdult subjectAnti-Obesity Agents subjectBlood Glucose subjectBlood Pressure subjectBody Mass Index subjectClinical Trial subjectDouble-Blind Method subjectFemale subjectHumans subjectJournal Article subjectMale subjectMiddle Aged subjectObesity subjectRandomized controlled trials study

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