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Regional and statewide hysterectomy-corrected endometrial cancer incidence and five-year relative survival in Texas.

Akemi T Wijayabahu·Nicolas Wentzensen·Nameer B Kirma·Lillian Lin-Smith·Wayne R Lawrence·Chen-Pin Wang·Edward R Kost
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Abstract

BACKGROUND: Rising endometrial cancer (EC) incidence nationwide, particularly among Hispanic women, and high prevalence of risk factors such as obesity and comorbidities in Texas, motivated us to estimate EC incidence rates (IRs) and survival by age (<50 years/ early-onset, &#x2265;50 years/late-onset), race-ethnicity (Non-Hispanic-White [NHW], -Black [NHB], Hispanic), histology (endometrioid, non-endometrioid), and area-based socioeconomic (SES) factors across Texas Health Service Regions (HSRs). STUDY DESIGN: Between 2000 and 2019, a total of 42,571 women (20-79 years) with EC were reported from Texas within the Surveillance, Epidemiology, and End Results Program. IRs and 5-year relative survival were calculated using SEER*Stat. IRs were corrected for hysterectomy using Behavioral Risk Factor Surveillance System data. RESULTS: Statewide EC IRs rose from 38.5 (2000-2009) to 44.5 (2010-2019), with the highest increase in the Upper-South (42.6 to 53.8). Across HSRs, Upper-South consistently had higher IRs among women <&#x202f;50 (13.9) and &#x2265;&#x202f;50 years (112.7). Among those <&#x202f;50 years, Hispanics had the highest IRs (12.4), predominantly endometrioid tumors, whereas in women &#x2265;&#x202f;50 years, NHB had the highest IRs (119.2) with a large proportion of non-endometrioid tumors. IRs were higher in areas with lower poverty, and higher education, income, and urbanization. Associations with unemployment were mixed. Worse survival outcomes were observed among NHBs, non-endometrioid, advanced-stage, and lower SES. Central Texas had more favorable survival outcomes compared to other HSR. CONCLUSION: EC IRs and survival rates in Texas largely mirror national trends, with regional differences likely reflecting sociodemographic and histologic distributions.

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HumansFemaleEndometrial NeoplasmsTexasMiddle AgedIncidenceAdultSEER ProgramAgedHysterectomyRisk FactorsYoung AdultSurvival RateSocioeconomic FactorsEndometrial cancerHistologyIncidence ratesRace-ethnicitySurvivalJournal Article

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Akemi T Wijayabahu, Nicolas Wentzensen, Nameer B Kirma, Lillian Lin-Smith, Wayne R Lawrence, Chen-Pin Wang, Edward R Kost. 2026-07-20. Regional and statewide hysterectomy-corrected endometrial cancer incidence and five-year relative survival in Texas.. https://doi.org/10.1016/j.canep.2026.103160

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