Preparation and study of non-thrombotic and biostable sulfobetaine-modified small-diameter polyurethane vascular grafts.

Zhihua Liu; Yuting Ge; Yi Wei; Zhengjian Zhang; Yuehao Xing; Lin Ye; Zeng-Guo Feng; Jinyu Wu; Yonghao Xiao

doi:10.1016/j.colsurfb.2026.115979

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Preparation and study of non-thrombotic and biostable sulfobetaine-modified small-diameter polyurethane vascular grafts.

Zhihua Liu·Yuting Ge·Yi Wei·Zhengjian Zhang·Yuehao Xing·Lin Ye·Zeng-Guo Feng·Jinyu Wu·Yonghao Xiao

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Abstract

A novel sulfobetaine-modified polysiloxane-polycarbonate polyurethane (ZSiPCU) was synthesized. In vitro characterizations revealed that polysiloxane surface enrichment endowed the material with excellent biostability. Importantly, sulfobetaine zwitterions formed a robust hydration layer, effectively suppressing protein adsorption and platelet adhesion to ensure outstanding hemocompatibility. Furthermore, the material supported the adhesion and proliferation of vascular endothelial cells, confirming its cytocompatibility, while its elastomeric matrix provided rapid mechanical self-sealing capabilities. Electrospun ZSiPCU grafts were evaluated in a 3-month rat abdominal aorta model, maintaining high patency rates and facilitating in situ luminal endothelialization and smooth muscle cell remodeling. Additionally, superior puncture resistance of the grafts was demonstrated by puncture tests, with complete hemostasis achieved within 2 mins through mechanical self-sealing.

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Polyurethanes Animals Betaine Rats Platelet Adhesiveness Blood Vessel Prosthesis Biocompatible Materials Cell Proliferation Cell Adhesion Surface Properties Humans Siloxanes Polycarbonates Anticoagulation Endothelialization Polyurethane Small-diameter vascular grafts Sulfobetaine Journal Article

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Zhihua Liu, Yuting Ge, Yi Wei, Zhengjian Zhang, Yuehao Xing, Lin Ye, Zeng-Guo Feng, Jinyu Wu, Yonghao Xiao. 2026-07-11. Preparation and study of non-thrombotic and biostable sulfobetaine-modified small-diameter polyurethane vascular grafts.. https://doi.org/10.1016/j.colsurfb.2026.115979

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Journal Article resource Animals subject Biocompatible Materials subject Cell Proliferation subject Humans subject Journal Article subject Platelet Adhesiveness subject Polycarbonates subject Polyurethane subject Polyurethanes subject

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