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A MIL-88@Ru-based molecularly imprinted electrochemiluminescence sensor for highly selective and sensitive detection of enrofloxacin residues in animal-derived foods.

Juncai Jiang·Xiaofeng Wei·Huachang Zhang·Ruizhong Zhang·Daqian Song·Lan Ding·Yanhua Chen
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Abstract

Using a metal-organic framework (MOF) - supported Ru(bpy)32+ (MIL-88@Ru) composite luminescent material, this study innovatively adopted electropolymerization to fabricate a molecularly imprinted polymer-based electrochemiluminescent (MIP-ECL) sensor for enrofloxacin (ENR) detection in animal-derived foods. Systematic investigation of the ECL luminescence and ENR's quenching mechanism confirmed that the sensor integrates ECL's high sensitivity and MIP's high specificity, enabling rapid and accurate recognition of ENR. Experimental results show a good linear response in the range of 1 nmol/L-20 μmol/L (R2 = 0.99), a limit of detection (LOD) as low as 0.28 nmol/L, as well as excellent selectivity and stability. Recoveries of ENR in all investigated matrices ranged from 97.7% to 106.4%, confirming the reliability of the established method. This ECL-MIP coupling strategy provides a new technical approach and application references for the efficient detection of trace pollutants in food safety and environmental monitoring fields.

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EnrofloxacinAnimalsFood ContaminationLuminescent MeasurementsMolecular ImprintingElectrochemical TechniquesLimit of DetectionMetal-Organic FrameworksAnti-Bacterial AgentsDrug ResiduesMeatElectrochemiluminescence (ECL)Enrofloxacin detectionMetal-organic frameworkMolecular imprintingRu(bpy)(3)(2+)Journal ArticleEvaluation Study

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Juncai Jiang, Xiaofeng Wei, Huachang Zhang, Ruizhong Zhang, Daqian Song, Lan Ding, Yanhua Chen. 2026-07-07. A MIL-88@Ru-based molecularly imprinted electrochemiluminescence sensor for highly selective and sensitive detection of enrofloxacin residues in animal-derived foods.. https://doi.org/10.1016/j.foodchem.2026.150328

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Animals subjectAnti-Bacterial Agents subjectElectrochemical Techniques subjectFood Contamination subjectJournal Article subjectLimit of Detection subjectMeat subject

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