Levodopa-induced dyskinesia is still a major clinical problem in Brazilian movement disorder clinics.

Vitor Tumas; Manuelina Mariana Capellari Macruz Brito; Vanderci Borges; Henrique Ballalai Ferraz; Cyrus P Zabetian; Ignacio F Mata; Bruno Lopes Santos-Lobato

doi:10.1055/s-0045-1806922

PubMed · 40393687

Levodopa-induced dyskinesia is still a major clinical problem in Brazilian movement disorder clinics.

Vitor Tumas·Manuelina Mariana Capellari Macruz Brito·Vanderci Borges·Henrique Ballalai Ferraz·Cyrus P Zabetian·Ignacio F Mata·Bruno Lopes Santos-Lobato

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Abstract

Levodopa-induced dyskinesia (LID) remains a significant motor complication in Parkinson's disease (PD), although opinions differ on its clinical relevance.To explore the current prevalence and impact of LID, we analyzed two cohorts from the Latin American Research Consortium on the Genetics of Parkinson's Disease from movement disorder clinics in the city of São Paulo, Brazil, recruited 10 years apart.The cohorts included 187 individuals diagnosed with PD in phase 1 (2007-2014) and 224 in phase 2 (2021-2022). The presence and functional impact of LID were measured using part IV (items 4.1 and 4.2 respectively) of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS).The analysis revealed that LID frequency increased from 34.7 in phase 1 to 54.9% in phase 2 (more recent), with functional impact rising from 25.1 to 38.8%.The findings suggest that LID remains a relevant clinical issue in clinics specialized in movement disorders in Brazil, with no reduction in prevalence throughout the last decade. Further studies from other regions and less specialized neurology centers may help understand this motor complication in Brazil and in other developing countries.

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Humans Levodopa Brazil Male Dyskinesia, Drug-Induced Female Antiparkinson Agents Parkinson Disease Middle Aged Prevalence Aged Severity of Illness Index Adult Cohort Studies Journal Article

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Vitor Tumas, Manuelina Mariana Capellari Macruz Brito, Vanderci Borges, Henrique Ballalai Ferraz, Cyrus P Zabetian, Ignacio F Mata, Bruno Lopes Santos-Lobato. 2025-05-20. Levodopa-induced dyskinesia is still a major clinical problem in Brazilian movement disorder clinics.. https://doi.org/10.1055/s-0045-1806922

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