Ganglioside headgroups decrease lipid order in reconstituted phosphatidylcholine liposomes.

M Ollmann; H J Galla

doi:10.1016/0014-5793(85)80214-3

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Ganglioside headgroups decrease lipid order in reconstituted phosphatidylcholine liposomes.

M Ollmann·H J Galla

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Abstract

The effect of oligosaccharide carrying lipids on membrane fluidity has been investigated. Gangliosides GM1 and GQ1 were reconstituted into phosphatidylcholine bilayer membranes at low concentrations (less than 5 mol%). A strong fluidizing effect was observed leading to a suppression of the phase transition temperature. This was most pronounced with highly sialylated gangliosides. Ca2+ reverses the effect due to phase separation phenomena. We assume a hydrophilic lipid-lipid interaction in accordance with previously studied glycoprotein-lipid interactions.

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Animals Brain Chemistry Chemical Phenomena Chemistry Gangliosides Liposomes Membrane Fluidity Phosphatidylcholines Structure-Activity Relationship Swine Thermodynamics Comparative Study Journal Article Research Support, Non-U.S. Gov't

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M Ollmann, H J Galla. 1985-01-01. Ganglioside headgroups decrease lipid order in reconstituted phosphatidylcholine liposomes.. https://doi.org/10.1016/0014-5793(85)80214-3

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