PubMed · 395607
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A Violante, U Fantoli, M Palombi, C Floriani. 1979. [Some considerations on chronopathology].. https://pubmed.ncbi.nlm.nih.gov/395607/
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BACKGROUND: To investigate chronological changes of subjective symptoms during a normal pregnancy in nulliparous and multiparous women. METHODS: Prospective data were collected using a 20-item questionnaire (general fatigue, headache, palpitation, nausea/vomiting, fever, insomnia, edema, abnormal abdominal size, urinary frequency, lumbago, fetal descent, genital bleeding, watery discharge, high frequency of uterine contraction, increase in frequency of uterine contraction, strong intensity of uterine contraction, increase in intensity of uterine contraction, no change of uterine contraction at rest, high frequency of fetal movements, strong intensity of fetal movements) at Tsushima Izuhara Hospital in Nagasaki Prefecture, Japan. Seven hundred and twenty-nine nulliparous and 588 multiparous normal pregnant women were questioned from 1988 to 1992. A simple (chi-square test) analysis of appearance percentages in each item for every term of pregnancy was made. RESULTS: Each symptom showed different chronological patterns. In the simple analysis, there were significant differences (p < 0.05) in 10 symptoms (headache, palpitation, fever, insomnia, lumbago, fetal descent, watery discharge, increase in frequency of uterine contraction, strong intensity of uterine contraction, strong intensity of fetal movements) between nulliparous and multiparous subjects. In the multiparous group, there was a higher severity in eight of the ten symptoms, except for fever and watery discharge. CONCLUSIONS: The multiparous group had more complaints than did the nulliparous subjects. These normal patterns are of practical clinical use concerning subjective symptoms of pregnancy.
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Published in 1975, the Atlas of Cancer Mortality for U.S. Counties: 1950-1969 proved useful in identifying geographic patterns, especially clusters of high-rate areas, that have stimulated further epidemiologic study of specific cancer sites. These data have been updated to include population and mortality statistics through 1980. Our new atlas presents static maps of area-specific mortality rates for each decade from 1950 to 1980 among white males and females for 33 cancer sites, along with dynamic maps illustrating the trends in these rates over time. Although the geographic distribution of mortality rates has become more uniform for most cancer sites, clusters of high-rate areas have persisted for several common tumors. However, some new patterns have appeared, notably the emergence of several high-rate areas for lung cancer among women. Possible explanations for the geographic peculiarities of cancer are considered, based on the results of correlation and analytic studies prompted by the earlier maps. These successive studies indicate the value of monitoring mortality statistics on a small-area scale as a strategy for generating etiologic clues and targeting epidemiologic research, although one must be mindful of geographic fluctuations in diagnostic and reporting practices, survival rates, and migration patterns.