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Early decrease in total hemolytic complement activity (CH100) after fasting or intestinal bypass in the rat.

M Montanari·V Violi·M Muri·L Roncoroni·G Mora·M Ronzoni
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Abstract

An evaluation of total hemolytic complement activity (CH100) after fasting or intestinal bypass was performed in rats. The experiment lasted 6 days. Three groups, of 5 animals each, were studied. On the 1st day, basal values of total complement (TC), albumin and body weight were determined. Group A received normal, ad libitum feeding, group B started on a 'water only' diet, group C underwent intestinal bypass. On the 4th and 6th day the parameters were assessed. TC mean values were significantly lower in groups B and C, as compared to group A, on the 4th as well as on the 6th day (p less than 0.01 by Mann-Whitney's U test). Body weight showed a similar trend. Differences in albumin were never statistically significant. Limitations of the analytical method are discussed. The data show that fasting or bypass-induced malabsorption may determine an early decrease in total hemolytic complement activity, though a development of an immune deficiency is not proved.

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AnimalsBody WeightComplement System ProteinsFastingFemaleJejunoileal BypassMalabsorption SyndromesNutrition DisordersRatsRats, Inbred StrainsSerum AlbuminJournal Article

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M Montanari, V Violi, M Muri, L Roncoroni, G Mora, M Ronzoni. 1986. Early decrease in total hemolytic complement activity (CH100) after fasting or intestinal bypass in the rat.. https://doi.org/10.1159/000128503

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