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PubMed · 3937541

Lateralized decrease in self-stimulation induced by haloperidol in rats with unilateral 6-hydroxydopamine lesions.

R J Carey
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Abstract

Rats with bilateral hypothalamic electrode placements which generated similar self-stimulation rate-intensity functions were subjected to unilateral injections of 6-hydroxydopamine (6-OHDA) into A9 and A10 areas. Following 12 weeks of postoperative recovery which was bilaterally symmetrical the rats were administered 0.1 mg/kg haloperidol. In sham- and vehicle-injected control rats the haloperidol produced bilaterally symmetrical decreases in self-stimulation. In the rats with 6-OHDA lesions the haloperidol effect was asymmetric with a much greater decrease in self-stimulation evident for electrode placements in the dopamine deficient hemisphere than for electrodes in the non-lesion hemisphere. Biochemical evaluation of the lesions indicated that dopamine was severely depleted in limbic and striatal forebrain areas. The combined use of a lesion with a pharmacological blockade of a neurotransmitter system appears to be an effective technique to distinguish reward versus performance effects of the transmitter on self-stimulation.

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AnimalsBiogenic AminesCaudate NucleusDominance, CerebralDopamineHaloperidolHydroxydopaminesHypothalamusLimbic SystemMaleOxidopamineRatsRats, Inbred StrainsSelf StimulationJournal Article

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BibTeXRIS

R J Carey. 1985. Lateralized decrease in self-stimulation induced by haloperidol in rats with unilateral 6-hydroxydopamine lesions.. https://doi.org/10.1016/0166-4328(85)90029-4

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