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PubMed · 3804537

Anterior hypothalamic lesions decrease anaphylactic contractions in guinea pig trachea in vitro by reducing histamine and LTC4 reactivity.

A J Van Oosterhout·F P Nijkamp
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Abstract

Discrete lesions in the anterior hypothalamus (AHA) of the guinea pig brain reduce the anaphylactic contraction of the trachea in vitro after active in vivo sensitization by 40%. This difference in anaphylactic contraction does not correlate with a difference in homocytotropic antibodies but coincides with a decreased smooth muscle response to the anaphylactic mediators histamine and leukotriene C4. No difference in the beta-adrenoceptor function of the tracheal preparations can be found. The results suggest that AHA lesions afford protection against anaphylaxis in actively sensitized guinea pigs at least in part through a reduced smooth muscle response to anaphylactic mediators.

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AnaphylaxisAnimalsDose-Response Relationship, DrugGuinea PigsHistamineHypothalamus, AnteriorImmunization, PassiveImmunoglobulinsIn Vitro TechniquesMaleMuscle ContractionSRS-ATracheaJournal ArticleResearch Support, Non-U.S. Gov't

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A J Van Oosterhout, F P Nijkamp. 1986. Anterior hypothalamic lesions decrease anaphylactic contractions in guinea pig trachea in vitro by reducing histamine and LTC4 reactivity.. https://doi.org/10.1016/0192-0561(86)90100-1

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