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Intraventricular bombesin can decrease single meal size in the baboon.

D P Figlewicz·A Sipols·D Porte·S C Woods
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Abstract

We have reported that intravenous bombesin decreases single meal size in a dose-dependent manner. The present study tests whether intraventricular bombesin is also effective in decreasing single meal size. Doses of bombesin (0.1-4 micrograms/kg) were administered both intravenously and intraventricularly. A median dose of 1 microgram/kg bombesin decreased 30 min meal size about 50%, whereas a median dose of 1 microgram/kg given intravenously only decreased meal size 25%. We conclude that bombesin given centrally in the baboon can decrease meal size and that this effect does not appear to be due to leakage into the periphery.

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AnimalsBombesinFeeding BehaviorInfusions, IntravenousInjections, IntraventricularMalePapioJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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D P Figlewicz, A Sipols, D Porte, S C Woods. 1986. Intraventricular bombesin can decrease single meal size in the baboon.. https://doi.org/10.1016/0361-9230(86)90222-4

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