Search PubMed⌕ Search

PubMed · 3633596

Chest pain.

Abstract

The purpose of this article has been to review the multiple causes of chest pain. Because acute chest pain can be the only presenting symptom of a potentially life-threatening illness, it is important that the physician identify these patients rapidly and arrange appropriate hospital care. Likewise, it is also important that the physician recognize the less severe causes of chest pain so that the patient can be appropriately reassured in the office or sent for evaluation of the cause of this pain. Although nearly every patient with acute chest pain views this pain as an emergency, the majority of patients with this type of pain presenting to a physician's office can be evaluated and reassured using only basic office skills.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

G M Owens. 1986. Chest pain.. https://pubmed.ncbi.nlm.nih.gov/3633596/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes and stable angina pectoris.

OBJECTIVE: Ischemic preconditioning is an increased tolerance to myocardial ischemia during the second of two consecutive exercise tests. ATP-sensitive K(+) channel blockers, such as glinides and sulfonylurea drugs, can induce loss of ischemic preconditioning. This study aimed to investigate the effects of repaglinide, a hypoglycemic agent with an affinity for myocardial ATP-sensitive K (+)channels, on the results of consecutive exercise tests in patients with diabetes and multivessel coronary artery disease. METHODS: Forty-two patients with type 2 diabetes and chronic stable angina pectoris, and two-vessel or three-vessel disease participated in this study. The patients underwent two consecutive treadmill exercise tests (phase 1). On the day after these exercise tests, 2 mg of oral repaglinide was given to the patients. One week later, two exercise tests were repeated consecutively (phase 2). RESULTS: All patients achieved 1.0-mm ST-segment depression during the four exercise tests (T1, T2, T3, and T4). In phase 2, seven patients improved in time to onset of 1.0-mm ST-segment depression. The worsening of the time to onset of 1.0-mm ST-segment depression in phase 2 demonstrated ischemic preconditioning block in 83.3% of patients (P=0.0001). Even the postexercise electrocardiographic parameters (ST-segment depression morphology and magnitude and arrhythmias) were significantly different between the groups with and without pharmacologic ischemic preconditioning block (P=0.031). CONCLUSIONS: Repaglinide, an oral hypoglycemic agent with ATP-sensitive K(+) channel-blocker activity, eliminated the myocardial ischemic preconditioning in patients with coronary disease and diabetes.

Angina Pectoris↗