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PubMed · 3208688

[Decrease in the antimetastatic effect of vinblastine administered in liposomes].

V I Kaledin·N A Popova·V P Nikolin·L A Semenova·V G Budker
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Abstract

The model of experimental metastases in the HA-1 tumour in the liver of A/He mice was used to show that the anti-tumoural effect of cis-dichlorodiamminoplatinum being used in the liposomes increases, while that of vinblastine (VB) decreases. It is suggested that the low activity of liposome-encapsulated VB as to its influence on the tumour growth in the liver is a result of preferable uptake of liposomes by Kupffer cells and hepatocytes from where VB cannot diffuse into tumour cells since it binds to intracellular tubulin.

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AnimalsDrug CarriersLiposomesLiver Neoplasms, ExperimentalMiceMice, Inbred ANeoplasm MetastasisVinblastineComparative StudyEnglish AbstractJournal Article

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V I Kaledin, N A Popova, V P Nikolin, L A Semenova, V G Budker. 1988. [Decrease in the antimetastatic effect of vinblastine administered in liposomes].. https://pubmed.ncbi.nlm.nih.gov/3208688/

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