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PubMed · 2902935

Selective decrease in Leu8-negative T cell subpopulations following treatment with recombinant interferon-alpha 2a (rIFN-alpha 2a).

O Martínez-Maza·R A Figlin·J V Giorgi·J L Fahey
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Abstract

The effects of in vivo treatment with recombinant human IFN-alpha 2a (rIFN-alpha 2a) on the distribution of T cell subpopulations were examined in 21 patients with renal cell adenocarcinoma, using two-color flow cytometry with anti-Leu8 in combination with anti-Leu2 and anti-Leu3. Other parameters indicative of immune status, such as the number and percentage of total (CD3) T cells, in vitro proliferation to mitogen, and spontaneous immunoglobulin secretion, were also measured, prior to the initiation of treatment with rIFN-alpha 2a, and during treatment. Total T cell number decreased after treatment with rIFN-alpha 2a, to a low of 54% of mean pretreatment values after 4 weeks. The CD4/CD8 ratio did not change appreciably following treatment with rIFN-alpha 2a. However, the number of Leu8-negative T cells, within both the CD4 and the CD8 T cell populations, decreased more than the number of Leu8-positive T cells. An increase in spontaneous immunoglobulin-secreting cells followed treatment with rIFN-alpha 2a.

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Antibodies, MonoclonalAntibody-Producing CellsAntigens, Differentiation, T-LymphocyteCD4-Positive T-LymphocytesCarcinoma, Renal CellFlow CytometryHumansImmunotherapyInterferon Type IInterferon alpha-2Interferon-alphaKidney NeoplasmsLeukocyte CountRecombinant ProteinsT-LymphocytesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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O Martínez-Maza, R A Figlin, J V Giorgi, J L Fahey. 1988. Selective decrease in Leu8-negative T cell subpopulations following treatment with recombinant interferon-alpha 2a (rIFN-alpha 2a).. https://doi.org/10.1016/0008-8749(88)90079-2

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