Decrease in the c-myb gene transcript during differentiation of mouse teratocarcinoma stem cells.

M Fukuda; S Ikuma; C Setoyama; K Shimada

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Decrease in the c-myb gene transcript during differentiation of mouse teratocarcinoma stem cells.

M Fukuda·S Ikuma·C Setoyama·K Shimada

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Abstract

Transcript of the c-myb gene, one of the proto-oncogenes, was clearly detected in undifferentiated mouse F9 teratocarcinoma stem cells, but not in terminally differentiated mouse parietal endoderm PYS-2 cells. As F9 cells can be induced to differentiate into parietal endoderm-like cells by the addition of retinoic acid and dibutyryl cAMP, we examined levels of the c-myb transcript under this experimental condition and found that the c-myb transcript was decreased significantly. Thus, a decrease in the c-myb transcript is probably related to early differentiation of mammalian cells.

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Animals Bucladesine Cell Differentiation Cell Line DNA, Neoplasm Embryonal Carcinoma Stem Cells Mice Neoplastic Stem Cells Proto-Oncogenes RNA, Messenger Teratoma Transcription, Genetic Tretinoin Journal Article Research Support, Non-U.S. Gov't

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M Fukuda, S Ikuma, C Setoyama, K Shimada. 1987. Decrease in the c-myb gene transcript during differentiation of mouse teratocarcinoma stem cells.. https://pubmed.ncbi.nlm.nih.gov/2840075/

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