Surfactant therapy.

B Lachmann

doi:10.1016/0300-9572(89)90052-x

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PubMed · 2555887

Surfactant therapy.

B Lachmann

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Abstract

This paper presents the rationale for surfactant replacement therapy. In 6 animal models in which respiratory failure was induced by damaging the bronchial surfactant, surfactant depletion by lung lavage, by free oxygen radicals, by influenza virus and by anti-lung serum, it is demonstrated that surfactant instillation always led to an improvement in gas exchange and lung mechanics. A first clinical trials shows that surfactant instillation also improved lung function in a patient with severe respiratory failure. It is speculated that surfactant replacement therapy will become an acceptable therapeutic measure for treating lung failure in patients suffering with ARDS.

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Animals Disease Models, Animal Humans Pulmonary Surfactants Respiratory Distress Syndrome Journal Article Review

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B Lachmann. 1989. Surfactant therapy.. https://doi.org/10.1016/0300-9572(89)90052-x

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