PubMed · 2535629
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
B T Stephens. 1989. AIDS discrimination.. https://pubmed.ncbi.nlm.nih.gov/2535629/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
The natural history and progression of HIV-1 infection in Thailand and other developing countries in Asia and Africa have not been well defined. Nevertheless, valid data are needed to evaluate the effects of interventions, which are designed to delay progression. We evaluated the progression to AIDS and death in 235 men who seroconverted during their 2 years of service in the Royal Thai Army. The men were conscripted at age 21 and seroconverted within a 6-month window during follow-up while in the military. The seroconverters were matched with men who were seronegative when discharged. Of the HIV-positive men, 156 (66.4%) were alive, 77 (32.8%) had died, and 2 (0.8%) could not be located 5-7 years after their seroconversion and discharge from the military. The 5-year survival rate was 82.3%; the median times to clinical AIDS and a CD4 cell count of <200/microL was 7.4 years and 6.9 years, respectively. The mortality rate was 56.3 deaths per 1000 patient-years for HIV-positive men and 6.1 deaths per 1000 patient-years for HIV-negative men. Our data suggest a more rapid progression to AIDS and death after HIV-1 infection in young men in Thailand than has been reported for similarly aged cohorts in developed countries.
OBJECTIVES: HIV spread rapidly in Namibia in the 1990s. As in most of Africa, however, few data exist to document the impact on mortality of AIDS. Such data can contribute to knowledge of the epidemiology of HIV infection and inform the development of programmes to mitigate the impact of the AIDS epidemic. DESIGN: This study analyses death records from the registers of eight Evangelical Lutheran parishes in northern Namibia. The dataset covers the experience between 1980 and January 2001 of 4680 couples who married between 1956 and 2000 and their children. METHODS: We examine trends in post-neonatal and 1-4-years mortality, and the age-standardized death rates at age 20-64 years of both men and women. Poisson regression for rates is used to smooth the data and test for statistically significant discontinuities in the trend. RESULTS: Post-neonatal mortality increased more than sixfold and 1-4-years mortality more than threefold between 1991 and 2000. By 2000 adult mortality for women was 3.5 times, and for men 2.5 times its 1993 level. The increase in adult mortality was concentrated at ages 30-54 years for men and 25-49 years for women. CONCLUSIONS: The pattern of mortality increase by age is consistent with the hypothesis that it is entirely due to AIDS. While not widely available, parish registers exist elsewhere in Africa and are potentially a low-cost source of data for study of the impact of AIDS on mortality and demographic trends more generally.
The study of true seronegative HIV-1 infections may have important implications for the diagnosis and prevention of HIV-1 infection. The case of an AIDS patient with persistently negative HIV serology is described. Genetic and phylogenetic analysis indicated that she was infected with A2 subsubtype HIV-1 transmitted by her seropositive and asymptomatic sexual partner. The clinical and serological discordant results suggest the presence of an immunological deficiency that prevents the formation of HIV-1-specific antibodies.