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PubMed · 2454889

Interferons.

A G Morris
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Abstract

Interferon (IFN)-alpha and -beta are produced by virus-infected cells; IFN-gamma is produced as a primary response of T lymphocytes to mitogenic stimulation, IFN-gamma gene activation being brought about by changes in Ca2+ and phosphatidyl inositol metabolism. IFNs act by binding to cell surface receptors and triggering activation of IFN-responsive genes, probably via specific base sequences located in the 5' non-coding region of such genes, resulting in changes in cell function. Important genes activated in this way are the MHC antigen genes; class I induced by all IFNs, class II by IFN-gamma only. This MHC activation may have important consequences for lymphocyte function.

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AnimalsChemical PhenomenaChemistryHLA AntigensInterferonsMiceJournal ArticleReview

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A G Morris. 1988. Interferons.. https://pubmed.ncbi.nlm.nih.gov/2454889/

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