PubMed · 2231992
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P M Paulman, K Cantral, J G Meade, K Vettel, R Loperena, M Odrezin. 1990-11-14. Dobutamine overdose.. https://pubmed.ncbi.nlm.nih.gov/2231992/
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BACKGROUND: We hypothesized that color encoding of endocardial motion could aid less-experienced readers in detection of wall-motion abnormalities at rest and stress in patients with poor acoustic windows. METHODS: Color-encoded images (color kinesis) were obtained at rest and peak dobutamine stress in 4 standard views during intravenous infusion of contrast agent in 117 patients with poorly visualized endocardium. In 101 of 117 patients (86%), in whom contrast enhancement allowed endocardial tracking, images were reviewed by two expert readers without color overlays. Each reader graded regional wall motion as normal, abnormal, or uninterpretable, and their consensus grades served as a gold standard. The same images were then reviewed and graded with and without color overlays by 3 cardiology fellows. The accuracy of the interpretation was calculated against the gold standard separately for the 3 vascular territories (left anterior descending, left circumflex, and right coronary arteries) and averaged for the 3 fellows. RESULTS: With the addition of color encoding: (1) the number of uninterpretable segments decreased by 55% at rest and 61% at peak stress; and (2) all 3 fellows reached higher levels of accuracy in all 3 vascular territories both at rest (6%-82% average) and at stress (73%-80%). CONCLUSION: The addition of color encoding of wall motion to contrast-enhanced images obtained in patients with poor acoustic windows during stress tests improves the interpretation of regional left ventricular function by less-experienced readers.
We compared particulate and microbial contamination in residual solutions of peripheral intravenous admixtures after the termination of drip infusion between intravenous fluids admixed with glass ampoule drugs and those admixed with pre-filled syringe drugs. The mean number of particles>or=1.3 microm in diameter per 1 ml of residual solution was 758.4 for fluids (n=60) admixed with potassium chloride in a glass ampoule (20 ml volume), 158.6 for fluids (n=63) admixed with potassium chloride in a pre-filled syringe (20 ml volume), 736.5 for fluids (n=66) admixed with sodium chloride in a glass ampoule (20 ml volume), 179.2 for fluids (n=15) admixed with sodium chloride in a pre-filled syringe (20 ml volume), 1884.5 in fluids (n=30) admixed with dobutamine hydrochloride in 3 glass ampoules (5 ml volume), and 178.9 (n=10) in diluted dobutamine hydrochloride in pre-filled syringes (50 ml volume: For these samples alone, particulate and microbial contamination were evaluated in sealed products.) Thus, for potassium chloride or sodium chloride for injection, the number of particles>or=1.3 microm in diameter in the residual intravenous solution was significantly higher for fluids admixed with glass ampoule drugs than for those admixed with pre-filled syringe drugs (p<0.0001). For dobutamine hydrochloride for injection, the number of particles>or=1.3 microm in diameter in the residual intravenous solution was estimated to be higher for fluids admixed with its glass ampoule drug than for those admixed with its pre-filled syringe drug. Observation of the residual solutions of fluids admixed with potassium chloride, sodium chloride, or dobutamine hydrochloride in glass ampoules using an electron microscope with an X-ray analyzer showed glass fragments in each residual solution. Therefore, for the prevention of glass particle contamination in peripheral intravenous admixtures, the use of pre-filled syringe drugs may a useful method. No microbial contamination was observed in any of the residual solutions of 5 types of admixture.
OBJECTIVES: The purpose of the study was to define an appropriate parameter for risk stratification and prognosis of patients undergoing stress echocardiography. BACKGROUND: Among stress echocardiography variables, peak wall-motion score index (WMSI) and ejection fraction (EF) have been shown to be independent and significant predictors of cardiovascular morbidity and mortality. Data on the impact and importance of each parameter in risk stratification and prognosis are limited. METHODS: We evaluated 1560 patients (59 +/- 13 years; 51% men) undergoing stress echocardiography (36% treadmill, 64% dobutamine). Peak WMSI was derived from the cumulative sum of 16 left ventricular segments divided by sum of visualized segments at peak stress. The ratio of peak WMSI to EF was calculated for the entire cohort. Based on this ratio and using the receiver operating characteristic curve, patients were divided into 3 groups: low- (< 1.9), intermediate- (1.9-3.1), and high- (> 3.1) risk subgroups. Follow-up (2.8 +/- 1.1 years) for confirmed myocardial infarction (n = 26) and cardiac death (n = 38) were obtained. RESULTS: Stress echocardiography effectively risk stratified patients into low- (0.7%/y), intermediate- (2.0%/y), and high- (4.4%/y) risk subgroups (P < .0001) based on the ratio of peak WMSI to EF. Cox proportional hazard model showed that risk stratification based on the ratio of peak WMSI to EF (global chi2 = 106.05; P < .0001) provided incremental value beyond that provided by risk stratification by peak WMSI (global chi2 = 79.23; P < .0001) or risk stratification by EF alone (global chi2 = 87.12; P < .0001). CONCLUSIONS: The ratio of peak WMSI to EF (stress function index) provides best incremental prognostic value and effectively risk stratifies patients into low-, intermediate-, and high-risk subgroups and is better than risk stratification by either peak WMSI or EF alone. The results of stress echocardiography should routinely combine peak WMSI and EF for effective risk stratification.