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PubMed · 2060587

Phosphatidylserine reverses the age-dependent decrease in cortical acetylcholine release: a microdialysis study.

F Casamenti·C Scali·G Pepeu
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Abstract

In vivo basal acetylcholine (ACh) and choline (Ch) output from the parietal cortex of 3- and 19-month-old freely moving rats was measured by microdialysis. A dialysis tubing was inserted transversally through the parietal cortex 24 h before the experiment. ACh and Ch concentrations were determined in the same perfusate samples by HPLC with electrochemical detection. In 19-month-old rats treated with Tris buffer, ACh and Ch outputs were 39 and 16% lower, respectively, than in 3-month-old rats. Phosphatidylserine (PtdSer) administration (15 mg/kg i.p. daily) for 8 days to 19-month-old rats markedly attenuated the decrease in ACh release. The same treatment did not affect ACh and Ch outputs in 3-month-old rats. ACh and Ch outputs in 19-month-old rats administered either phosphatidylcholine (PtdCho) or o-phospho-dl-serine (P-Ser) (15 mg/kg i.p. daily) for 8 days were as low as in 19-month-old rats receiving Tris buffer only. It is possible that chronic PtdSer treatment improve ACh release in aging rats by increasing the availability of Ch for ACh synthesis.

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AcetylcholineAgingAnimalsBrainBrain ChemistryCerebral CortexCholineChromatography, High Pressure LiquidDialysisMaleParasympathetic Nervous SystemParietal LobePhosphatidylserinesRatsJournal ArticleResearch Support, Non-U.S. Gov't

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F Casamenti, C Scali, G Pepeu. 1991-02-26. Phosphatidylserine reverses the age-dependent decrease in cortical acetylcholine release: a microdialysis study.. https://doi.org/10.1016/0014-2999(91)90117-9

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