Perspectives on dialysis: a dialysis patient talks about the differences in dialysis centers.
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To elucidate the relative role of osmolar (sodium) and acetate shifts during dialysis, 6 patients with problems of overhydration underwent rapid ultrafiltration for 1 hr (mean weight reduction 2.0 kg), using the 1 m2 RP 6 dialyzer. Ultrafiltration was carried out at the beginning of each of 5 dialysis treatments at weekly intervals. Ultrafiltration was undertaken without dialysis (controls) and with simultaneous dialysis using acetate (40 mmoles/1) or bicarbonate (25 mmoles/1) in the dialysis fluid with dialyzate sodium concentration of 133 and 145 mmoles/1. The systolic blood pressure and mean arterial pressure which were stable with ultrafiltration only fell slightly when a high dialyzate sodium concentration was used and much further when the dialyzate sodium concentration was kept low. These changes were apparently related to the changes in plasma osmolality. Acetate had no effect on blood pressure at the higher sodium concentration, but a slight (insignificant) additive effect when used in the low-sodium dialyzate. Shifts in osmolality (sodium concentration) seem to be more important than the effect of acetate in inducing dialysis-associated hypotension.
A survey of 1293 patients in eighteen dialysis centres in Great Britain showed a highly significant rank correlation of the incidence of both fracturing dialysis osteodystrophy (osteomalacic dialysis osteodystrophy) and dialysis encephalopathy with the aluminium content of water used to prepare dialysate.
The authors interviewed hemodialysis patients, their families, and medical staff and found that some patients preferred dialysis at a medical facility, which allowed them to appear more "normal" before their children. Patients with more social support involved their children in dialysis at home. The author suggests that social support is of primary importance to the outcome of home dialysis and should be considered by physicians in the assessment of patient's suitability for home dialysis.
To assess whether phosphate depletion is an aetiological factor in osteomalacic dialysis osteodystrophy we undertook a prospective trial of phosphate-enriched dialysis fluid, in association with oral 1alpha-hydroxycholecalciferol, for this condition. Thirty patients started the trial; of the 27 who completed more than 6 months' treatment, 14 had iliac crest bone biopsies at the beginning and end of the treatment period. Side effects included pruritus, stiffness, and increase in corneal and vascular calcification. Only one patient showed histological improvement of osteomalacia, and eight deteriorated; in seven the osteitis fibrosa worsened. Myopathy showed some improvement in four patients, but became worse in four. This treatment does not seem to have a place in the routine management of non-hypophosphataemic patients on dialysis.
It is described how with a small personnel and material expenditure in a nephrologic ward since several years haemodialytic therapies are performed successfully and effectively. The expenses for this form of dialysis integrated into the ward were compared with those in the dialysis centre. Demands of cost and personnel are essentially lower. In this paper the suggestion shall be given to test the organization of similar dialysis units in other places. The fund at disposal would then used more rationally and the degree of care for patients who need this therapy improved.
Clinical experience with continuous ambulatory peritoneal dialysis (CAPD) is described in 12 patients. A survey over 8 months shows satisfactory results. Besides the numerous advantages of this treatment, peritonitis represents the main problem. Technical developments in the future will aim at a reduction of this risk.
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