PubMed · 2014120
Pathophysiology of sciatica.
Abstract
The exact pathophysiologic mechanisms behind sciatica are incompletely known; however, compression of spinal nerve roots is known to be correlated to both pain and neural dysfunction in a segmental distribution of that specific nerve root. Compression per se may impair the transport of nutrients to the nerve tissue in such a way that affects the nerve root function. There also might be a local affect on nerve roots or root sleeves by substances leaking from the degenerated intervertebral discs.
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K Olmarker, B Rydevik. 1991. Pathophysiology of sciatica.. https://pubmed.ncbi.nlm.nih.gov/2014120/
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