PubMed · 2013531
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W A Kuchera. 1991. Our osteopathic uniqueness needs nurturing.. https://pubmed.ncbi.nlm.nih.gov/2013531/
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We use a mathematical model to investigate how climbing fiber-dependent plasticity at granule cell to Purkinje cell (gr-->Pkj) synapses in the cerebellar cortex is influenced by the synaptic organization of the cerebellar-olivary system. Based on empirical studies, gr-->Pkj synapses are assumed to decrease in strength when active during a climbing fiber input (LTD) and increase in strength when active without a climbing fiber input (LTP). Results suggest that the inhibition of climbing fibers by cerebellar output combines with LTD/P to self-regulate spontaneous climbing fiber activity to an equilibrium level at which LTP and LTD balance and the expected net change in gr-->Pkj synaptic weights is zero. The synaptic weight vector is asymptotically confined to an equilibrium hyperplane defining the set of all possible combinations of synaptic weights consistent with climbing fiber equilibrium. Results also suggest restrictions on LTP/D at gr-->Pkj synapses required to produce synaptic weights that do not drift spontaneously.
Psychosomatic disease has become almost synonymous with stress-related diseases. It is defined as a somatic disorder with influences from various types of stress. The physical reactions to stress are generally divided into three principal areas:those affecting the autonomic nervous system, the endocrine system or the immune system. However, recent studies show that these three areas actually affect one another and this, in turn, affects the body's homeostasis. In the stress-filled environment we live in, on-going research on psychosomatic disease and stress will continue to play a vital role in the diagnosis and treatment of disease.
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