Pentobarbital blocks the stress-induced decrease in [3H]Ro 5-4864 binding in rat kidney.

R C Drugan; P V Holmes; A P Stringer

doi:10.1016/0006-8993(90)91834-4

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Pentobarbital blocks the stress-induced decrease in [3H]Ro 5-4864 binding in rat kidney.

R C Drugan·P V Holmes·A P Stringer

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Abstract

Exposure to environmental stress causes changes in the binding of [3H]Ro 5-4864 to peripheral benzodiazepine receptors (PBRs). The influence of the central nervous system (CNS) in these stress-induced modifications is unclear. The present study examined whether pretreatment with a dose-response regimen of sodium pentobarbital would impact the stress-induced reduction in renal PBR. Administration of either a sedative/ataxic (20 mg/kg) or hypnotic (60 mg/kg) dose of pentobarbital prior to stress blocks the stress-induced decrease of [3H]Ro 5-4864 binding to renal PBR in rat. These findings suggest that higher-order, supraspinal mechanisms play a critical role in marshalling the renal PBR changes in response to stress.

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Animals Benzodiazepinones Dose-Response Relationship, Drug Kidney Male Pain Measurement Pentobarbital Radioligand Assay Rats Rats, Inbred Strains Reaction Time Receptors, GABA-A Stress, Physiological Tritium Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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R C Drugan, P V Holmes, A P Stringer. 1990-12-03. Pentobarbital blocks the stress-induced decrease in [3H]Ro 5-4864 binding in rat kidney.. https://doi.org/10.1016/0006-8993(90)91834-4

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