Mitotic control.

J L Maller

doi:10.1016/0955-0674(91)90151-n

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Mitotic control.

J L Maller

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Abstract

1990 has been a year of continued exciting developments in cell cycle control. Progress has occurred in delineating the mechanism of activation of maturation-promoting factor during entry into mitosis and the mechanism of cyclin degradation responsible for exit from mitosis. Notable advances have also occurred in our understanding of the dependence of mitotic entry on completion of DNA synthesis. Both genetic and biochemical data link this crucial checkpoint to the function of the cdc25 gene product and the extent of phosphorylation of Tyr15 in cdc2 kinase.

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Animals CDC2 Protein Kinase Cell Cycle Cell Cycle Proteins DNA Replication Fungal Proteins Humans Maturation-Promoting Factor Mitosis Proteins cdc25 Phosphatases ras-GRF1 Journal Article Review

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J L Maller. 1991. Mitotic control.. https://doi.org/10.1016/0955-0674(91)90151-n

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