PubMed · 1798944
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J Molin. 1991-09-18. [Work environment. Set procedure behind orders].. https://pubmed.ncbi.nlm.nih.gov/1798944/
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Tandem modular proteins underlie the elasticity of natural adhesives, cell adhesion proteins, and muscle proteins. The fundamental unit of elastic proteins is their individually folded modules. Here, we use protein engineering to construct multimodular proteins composed of Ig modules of different mechanical strength. We examine the mechanical properties of the resulting tandem modular proteins by using single protein atomic force microscopy. We show that by combining modules of known mechanical strength, we can generate proteins with novel elastic properties. Our experiments reveal the simple mechanical design of modular proteins and open the way for the engineering of elastic proteins with defined mechanical properties, which can be used in tissue and fiber engineering.
The relationship between the two-state model of muscle contraction and multi-state models is examined from the perspective of matched asymptotic expansions, under the assumption that transition rates between attached states are fast compared to those between detached and attached states. A detailed formal analysis of a three-state model reveals that the classic Huxley (1957. Prog. Biophys. Biophys. Chem.7, 225-318) rate equation, as modified for thermodynamic self-consistency by Hill et al. (1975. Biophys. J.15, 335-372), governs the "outer" solution of the three-state equations. Thus, the two-state model remains a valid description of muscle dynamics on physiologically relevant time scales, which are slow compared to millisecond-scale transitions between attached states. But the asymptotic analysis reveals also that the cross-bridge force must be considered to be a nonlinear function of the cross-bridge strain, in contrast to the usual assumption of two-state models. This apparent, or effective, force is determined by both the intrinsic stiffness of the cross-bridge and the equilibrium distribution of cross-bridges among attached states. Further, the asymptotic analysis yields an expression for the energy liberation rate that implies a reduced rate in stretch vs. shortening. Some behaviors of multi-state models that are suggested by the three-state analysis are discussed in qualitative terms.
This study shows that a corpus of proto-word forms shares four sequential sound patterns with words of modern languages and the first words of infants. Three of the patterns involve intrasyllabic consonant-vowel (CV) co-occurrence: labial (lip) consonants with central vowels, coronal (tongue front) consonants with front vowels, and dorsal (tongue back) consonants with back vowels. The fourth pattern is an intersyllabic preference for initiating words with a labial consonant-vowel-coronal consonant sequence (LC). The CV effects may be primarily biomechanically motivated. The LC effect may be self-organizational, with multivariate causality. The findings support the hypothesis that these four patterns were basic to the origin of words.