Retigabine.

Roger J Porter; Virinder Nohria; Chris Rundfeldt

doi:10.1016/j.nurt.2006.11.012

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PubMed · 17199031

Retigabine.

Roger J Porter·Virinder Nohria·Chris Rundfeldt

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Abstract

Retigabine is a novel antiseizure drug that acts through potassium channels and has activity in a broad range of animal models of epilepsy. It is also effective in several preclinical pain models. The drug has been extensively studied in phase I and II studies, with very promising results. The maximal tolerated dose for most patients is 1,200 mg/day. Adverse effects have been largely CNS-related and mild; most have occurred during the titration periods in the various studies. At present, retigabine is in two pivotal phase III studies.

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Roger J Porter, Virinder Nohria, Chris Rundfeldt. 2007. Retigabine.. https://doi.org/10.1016/j.nurt.2006.11.012

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