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PubMed · 17112593

In vivo sampling with solid phase microextraction.

Florin Marcel Musteata·Janusz Pawliszyn
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Abstract

This review discusses the most recent developments and future challenges in the application of solid phase microextraction (SPME) for sampling of live biological samples. The emphasis is placed on applications of fiber SPME for analysis of volatile emissions and drugs in biological fluids. The method development section highlights the main parameters that need to be considered in the case of in vivo experiments: extraction techniques, selection of extraction phases, calibration procedures, determination of free concentrations, and automation.

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Drug Evaluation, PreclinicalHumansOrganic ChemicalsSkinSolid Phase ExtractionSpecimen HandlingVolatilizationJournal ArticleReview

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BibTeXRIS

Florin Marcel Musteata, Janusz Pawliszyn. 2006-10-03. In vivo sampling with solid phase microextraction.. https://doi.org/10.1016/j.jbbm.2006.07.006

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