Combinatorial protein design strategies using computational methods.

Hidetoshi Kono; Wei Wang; Jeffery G Saven

doi:10.1385/1-59745-187-8:3

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Combinatorial protein design strategies using computational methods.

Hidetoshi Kono·Wei Wang·Jeffery G Saven

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Abstract

Computational methods continue to facilitate efforts in protein design. Most of this work has focused on searching sequence space to identify one or a few sequences compatible with a given structure and functionality. Probabilistic computational methods provide information regarding the range of amino acid variability permitted by desired functional and structural constraints. Such methods may be used to guide the construction of both individual sequences and combinatorial libraries of proteins.

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Amino Acid Sequence Combinatorial Chemistry Techniques Computational Biology Databases, Protein Gene Library Molecular Sequence Data Probability Protein Engineering Proteins Journal Article

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Hidetoshi Kono, Wei Wang, Jeffery G Saven. 2007. Combinatorial protein design strategies using computational methods.. https://doi.org/10.1385/1-59745-187-8%3A3

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