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PubMed · 17030055

Decrease in toxicity of microcystins LA and LR in drinking water by ozonation.

Samuel Brooke·Gayle Newcombe·Brenton Nicholson·Gunter Klass
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Abstract

Unchlorinated treated waters from two Australian reservoirs were spiked with microcystin-LA and -LR extracted from a toxic scum of Microcystis aeruginosa. The two waters had considerably different water quality and therefore ozone demands. The spiked sample waters were ozonated using the batch method of ozonation at a range of doses and the samples were analysed for toxins using high-performance liquid chromatography (HPLC). The toxin content of the samples was also determined using a protein phosphatase type 2A inhibition assay (PP2A) and toxicity via the standard mouse bioassay. The HPLC results correlated well with the PP2A results and toxicity tests for both waters. A loss of both toxins and toxicity was observed with increasing ozone dose, resulting in a complete loss of toxicity for both waters once an ozone residual had been achieved. At this ozone residual no toxin was detected using HPLC. The results indicate that microcystins are not transformed into toxic by-products.

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AnimalsAustraliaChromatography, High Pressure LiquidMarine ToxinsMiceMicrocystinsMicrocystisOzonePhosphoprotein PhosphatasesToxicity TestsWater Pollutants, ChemicalWater PurificationJournal Article

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Samuel Brooke, Gayle Newcombe, Brenton Nicholson, Gunter Klass. 2006-09-05. Decrease in toxicity of microcystins LA and LR in drinking water by ozonation.. https://doi.org/10.1016/j.toxicon.2006.08.010

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