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PubMed · 16961373

Polyester-based carborane-containing dendrons.

Kristin M Galie·Alexis Mollard·Ilya Zharov
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Abstract

New carborane-containing dendrons based on a 2,2-bis(hydroxymethyl)propanoic acid scaffold have been prepared for applications in boron neutron capture therapy. A generation-2 carborane-containing dendron carrying 40 boron atoms was the highest generation synthetically available due to the steric crowding. The structure of this dendron has been simulated by molecular dynamics. A 10-carbon linker carrying a carboxylic group has been installed at the focal point of the dendron to distance the attachment point from the sterically hindered core.

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Boron CompoundsComputer SimulationDendrimersModels, MolecularMolecular StructurePolyestersJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov't

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Kristin M Galie, Alexis Mollard, Ilya Zharov. 2006-09-18. Polyester-based carborane-containing dendrons.. https://doi.org/10.1021/ic060866r

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