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PubMed · 16920907

B-1 B cell development.

Richard R Hardy
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Abstract

CD5+ B cells have attracted considerable interest because of their association with self-reactivity, autoimmunity, and leukemia. In mice, CD5+ B cells are readily generated from fetal/neonatal precursors, but inefficiently from precursors in adult. One model proposed to explain this difference is that their production occurs through a distinctive developmental process, termed B-1, that enriches pre-B cells with novel germline VDJs and that requires positive selection of newly formed B cells by self-Ag. In contrast, follicular B cells are generated throughout adult life in a developmental process termed B-2, selecting VDJs that pair well with surrogate L chain, and whose maturation appears relatively independent of antigenic selection. In the present study, I focus on processes that shape the repertoire of mouse CD5+ B cells, describing the differences between B-1 and B-2 development, and propose a model encompassing both in the generation of functional B cell subpopulations.

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AnimalsB-LymphocytesCD5 AntigensCell DifferentiationCell LineageHumansLymphocyte ActivationModels, ImmunologicalJournal ArticleResearch Support, N.I.H., ExtramuralReview

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Richard R Hardy. 2006-09-01. B-1 B cell development.. https://doi.org/10.4049/jimmunol.177.5.2749

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