Bacterial complement evasion.

Suzan H M Rooijakkers; Jos A G van Strijp

doi:10.1016/j.molimm.2006.06.011

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PubMed · 16875737

Bacterial complement evasion.

Suzan H M Rooijakkers·Jos A G van Strijp

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Abstract

The human complement system is elemental to recognize bacteria, opsonize them for handling by phagocytes, or kill them by direct lysis. However, successful bacterial pathogens have in turn evolved ingenious strategies to overcome this part of the immune system. In this review we discuss the different stages of complement activation sequentially and illustrate the immune evasion strategies that various bacteria have developed to evade each subsequent step. The focus is on bacterial proteins, either surface-bound or excreted, that block complement activation. The underlying molecular mechanism of action and the possible role in pathophysiology of bacterial infections are discussed.

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Animals Bacterial Infections Bacterial Proteins CD59 Antigens Complement Activation Complement C1 Inhibitor Protein Complement C3 Complement C3-C5 Convertases Humans Receptors, Complement Journal Article Research Support, Non-U.S. Gov't Review

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Suzan H M Rooijakkers, Jos A G van Strijp. 2006-07-27. Bacterial complement evasion.. https://doi.org/10.1016/j.molimm.2006.06.011

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