Analysing the developing brain transcriptome with the GenePaint platform.

Gonzalo Alvarez-Bolado; Gregor Eichele

doi:10.1113/jphysiol.2006.112763

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Analysing the developing brain transcriptome with the GenePaint platform.

Gonzalo Alvarez-Bolado·Gregor Eichele

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Abstract

We discuss technical means by which the complexity of gene and protein signalling cascades can be projected onto the complex structure of the mammalian brain. We argue that this requires both robotics and novel computational tools to register images of gene expression, annotate expression patterns and quantify gene expression. When sufficiently enriched and detailed, such gene expression/neuroanatomical atlases are hypothesis-generating tools and contain in themselves much of the information needed to investigate function in normal and genetically or otherwise modified brains. To be successful and useful, data-rich and comprehensive gene expression/neuroanatomical atlases have to be web accessible and structured in a way that allows the application of data exploration and mining tools.

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Animals Brain Chromosome Mapping Databases, Genetic Gene Expression Profiling Gene Expression Regulation, Developmental Genes, Developmental Genome Humans In Situ Hybridization Internet Robotics Signal Transduction Software Transcription, Genetic Journal Article Research Support, Non-U.S. Gov't Review

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Gonzalo Alvarez-Bolado, Gregor Eichele. 2006-07-06. Analysing the developing brain transcriptome with the GenePaint platform.. https://doi.org/10.1113/jphysiol.2006.112763

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