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PubMed · 16777399

T cell-dendritic cell immunological synapses.

Michael L Dustin·Su-Yi Tseng·Rajat Varma·Gabriele Campi
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Abstract

Dendritic cells (DCs) are myeloid lineage cells that are imprinted by their environment and that mature in response to microbial products. A crucial role of the DC is to impart this context-specific information to T cells as well as to present self and foreign MHC-peptide complexes through formation of an immunological synapse. The structure of the T cell-DC immunological synapse departs from the canonical structure formed with B cells or with supported planar bilayers in that it has multiple foci of T-cell receptor interactions rather than a central focus. Recent studies on model systems provide insight into the mechanisms and biological consequences of the unique T cell-DC synaptic patterns.

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AnimalsCell CommunicationCell MembraneDendritic CellsHumansLipid BilayersT-LymphocytesJournal ArticleReview

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Michael L Dustin, Su-Yi Tseng, Rajat Varma, Gabriele Campi. 2006-06-13. T cell-dendritic cell immunological synapses.. https://doi.org/10.1016/j.coi.2006.05.017

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