Leukocyte function-associated antigen-1: structure, function and application prospects.

Ma Xingyuan; Zheng Wenyun; Wang Tianwen

doi:10.2174/092986606775974429

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Leukocyte function-associated antigen-1: structure, function and application prospects.

Ma Xingyuan·Zheng Wenyun·Wang Tianwen

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Abstract

This review focuses on the structure, function and pathological role of leukocyte function-associated antigen-1 (LFA-1) which is a heterodimeric protein consisting of two subunits. LFA-1 plays a most important role in the immune system including adhesion, extravasation, migration, apoptosis, cytotoxicity, cytokine production, and proliferation of lymphocytes. Therefore, T-cell activation can be suppressed by blocking ICAM-1/LFA-1 interaction in autoimmune diseases and organ transplantation. Many different inhibitors (i.e. antibodies, peptides, small molecules) have been demonstrated to block ICAM-1/LFA-1 interaction, and some of them are promising for medical treatment or have reached clinical trials.

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Animals Antigen-Presenting Cells Autoimmune Diseases Humans Intercellular Adhesion Molecule-1 Leukocyte-Adhesion Deficiency Syndrome Lymphocyte Function-Associated Antigen-1 T-Lymphocytes Journal Article Review

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Ma Xingyuan, Zheng Wenyun, Wang Tianwen. 2006. Leukocyte function-associated antigen-1: structure, function and application prospects.. https://doi.org/10.2174/092986606775974429

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