How a single protein complex accommodates many different H/ACA RNAs.

U Thomas Meier

doi:10.1016/j.tibs.2006.04.002

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How a single protein complex accommodates many different H/ACA RNAs.

U Thomas Meier

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Abstract

More than 100 mammalian H/ACA RNAs form an equal number of ribonucleoproteins (RNPs) by associating with the same four core proteins. The function of these H/ACA RNPs is essential for biogenesis of the ribosome, splicing of precursor mRNAs (pre-mRNAs), maintenance of telomeres and probably for additional cellular processes. Recent crystal structures of archaeal H/ACA protein complexes show how the same four proteins accommodate >100 distinct but related H/ACA RNAs and reveal that a spatial mutation cluster underlies dyskeratosis congenita, a syndrome of bone marrow failure.

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Animals Archaeal Proteins Dyskeratosis Congenita Mammals Mutation Protein Binding Protein Structure, Tertiary RNA Splicing RNA, Small Nuclear Ribonucleoproteins, Small Nucleolar Ribosomes Journal Article Research Support, N.I.H., Extramural Review

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U Thomas Meier. 2006-05-02. How a single protein complex accommodates many different H/ACA RNAs.. https://doi.org/10.1016/j.tibs.2006.04.002

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