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PubMed · 16631882

Mild cognitive impairment.

Serge Gauthier·Barry Reisberg·Michael Zaudig·Ronald C Petersen·Karen Ritchie·Karl Broich·Sylvie Belleville·Henry Brodaty·David Bennett·Howard Chertkow·Jeffrey L Cummings·Mony de Leon·Howard Feldman·Mary Ganguli·Harald Hampel·Philip Scheltens·Mary C Tierney·Peter Whitehouse·Bengt Winblad·International Psychogeriatric Association Expert Conference on mild cognitive impairment
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Abstract

Mild cognitive impairment is a syndrome defined as cognitive decline greater than expected for an individual's age and education level but that does not interfere notably with activities of daily life. Prevalence in population-based epidemiological studies ranges from 3% to 19% in adults older than 65 years. Some people with mild cognitive impairment seem to remain stable or return to normal over time, but more than half progress to dementia within 5 years. Mild cognitive impairment can thus be regarded as a risk state for dementia, and its identification could lead to secondary prevention by controlling risk factors such as systolic hypertension. The amnestic subtype of mild cognitive impairment has a high risk of progression to Alzheimer's disease, and it could constitute a prodromal stage of this disorder. Other definitions and subtypes of mild cognitive impairment need to be studied as potential prodromes of Alzheimer's disease and other types of dementia.

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AgedCholinergic AntagonistsClinical Trials as TopicCognition DisordersDementiaDisease ProgressionHumansMemorySeverity of Illness IndexJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Serge Gauthier, Barry Reisberg, Michael Zaudig, Ronald C Petersen, Karen Ritchie, Karl Broich, Sylvie Belleville, Henry Brodaty, David Bennett, Howard Chertkow, Jeffrey L Cummings, Mony de Leon, Howard Feldman, Mary Ganguli, Harald Hampel, Philip Scheltens, Mary C Tierney, Peter Whitehouse, Bengt Winblad, International Psychogeriatric Association Expert Conference on mild cognitive impairment. 2006-04-15. Mild cognitive impairment.. https://doi.org/10.1016/s0140-6736(06)68542-5

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