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PubMed · 16631259

CD24 Ala/Val polymorphism and multiple sclerosis.

An Goris·Melanie Maranian·Amie Walton·Tai Wai Yeo·Maria Ban·Julia Gray·Bénédicte Dubois·Alastair Compston·Stephen Sawcer
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Abstract

CD24 is expressed on a broad range of cells in the immune and central nervous systems and appears to be required for development of experimental autoimmune encephalomyelitis in mice. Association of a CD24 Ala/Val coding polymorphism with susceptibility to and progression of multiple sclerosis was recently reported. We typed this coding polymorphism in a combined cohort of 1,180 cases and 1,168 unrelated and family-based controls from Belgium and the UK, but were unable to confirm either association. Since the CD24 gene is part of a segmental duplication, special care is required for the identification and genotyping of single nucleotide polymorphisms.

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AlanineCD24 AntigenChemotaxis, LeukocyteDouble-Blind MethodFemaleHumansLongitudinal StudiesMaleMiddle AgedMitoxantroneMultiple Sclerosis, Chronic ProgressivePolymorphism, Single NucleotideReceptors, ChemokineValineClinical Trial, Phase IIComparative StudyJournal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov't

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An Goris, Melanie Maranian, Amie Walton, Tai Wai Yeo, Maria Ban, Julia Gray, Bénédicte Dubois, Alastair Compston, Stephen Sawcer. 2006-05-02. CD24 Ala/Val polymorphism and multiple sclerosis.. https://doi.org/10.1016/j.jneuroim.2006.03.009

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