No evidence for association of a European-specific chromosome 17 inversion with multiple sclerosis.
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Chromosome Inversion↗
Biomedical subjects
Amie Walton
Publications and source records attributed to Amie Walton.
CD24 Ala/Val polymorphism and multiple sclerosis.
CD24 is expressed on a broad range of cells in the immune and central nervous systems and appears to be required for development of experimental autoimmune encephalomyelitis in mice. Association of a CD24 Ala/Val coding polymorphism with susceptibility to and progression of multiple sclerosis was recently reported. We typed this coding polymorphism in a combined cohort of 1,180 cases and 1,168 unrelated and family-based controls from Belgium and the UK, but were unable to confirm either association. Since the CD24 gene is part of a segmental duplication, special care is required for the identification and genotyping of single nucleotide polymorphisms.
Alanine↗
No alterations in alpha-synuclein gene dosage observed in sporadic Parkinson's disease.
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Adult↗