Seizure detection algorithm for neonates based on wave-sequence analysis.

Michael A Navakatikyan; Paul B Colditz; Chris J Burke; Terrie E Inder; Jane Richmond; Christopher E Williams

doi:10.1016/j.clinph.2006.02.016

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PubMed · 16621690

Seizure detection algorithm for neonates based on wave-sequence analysis.

Michael A Navakatikyan·Paul B Colditz·Chris J Burke·Terrie E Inder·Jane Richmond·Christopher E Williams

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Abstract

OBJECTIVE: The description and evaluation of the performance of a new real-time seizure detection algorithm in the newborn infant. METHODS: The algorithm includes parallel fragmentation of EEG signal into waves; wave-feature extraction and averaging; elementary, preliminary and final detection. The algorithm detects EEG waves with heightened regularity, using wave intervals, amplitudes and shapes. The performance of the algorithm was assessed with the use of event-based and liberal and conservative time-based approaches and compared with the performance of Gotman's and Liu's algorithms. RESULTS: The algorithm was assessed on multi-channel EEG records of 55 neonates including 17 with seizures. The algorithm showed sensitivities ranging 83-95% with positive predictive values (PPV) 48-77%. There were 2.0 false positive detections per hour. In comparison, Gotman's algorithm (with 30s gap-closing procedure) displayed sensitivities of 45-88% and PPV 29-56%; with 7.4 false positives per hour and Liu's algorithm displayed sensitivities of 96-99%, and PPV 10-25%; with 15.7 false positives per hour. CONCLUSIONS: The wave-sequence analysis based algorithm displayed higher sensitivity, higher PPV and a substantially lower level of false positives than two previously published algorithms. SIGNIFICANCE: The proposed algorithm provides a basis for major improvements in neonatal seizure detection and monitoring.

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Algorithms Electroencephalography Epilepsy False Positive Reactions Humans Infant, Newborn Infant, Newborn, Diseases Models, Neurological Sensitivity and Specificity Clinical Trial Journal Article Research Support, Non-U.S. Gov't

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Michael A Navakatikyan, Paul B Colditz, Chris J Burke, Terrie E Inder, Jane Richmond, Christopher E Williams. 2006-04-19. Seizure detection algorithm for neonates based on wave-sequence analysis.. https://doi.org/10.1016/j.clinph.2006.02.016

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