Membrane binding domains.

James H Hurley

doi:10.1016/j.bbalip.2006.02.020

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Membrane binding domains.

James H Hurley

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Abstract

Eukaryotic signaling and trafficking proteins are rich in modular domains that bind cell membranes. These binding events are tightly regulated in space and time. The structural, biochemical, and biophysical mechanisms for targeting have been worked out for many families of membrane binding domains. This review takes a comparative view of seven major classes of membrane binding domains, the C1, C2, PH, FYVE, PX, ENTH, and BAR domains. These domains use a combination of specific headgroup interactions, hydrophobic membrane penetration, electrostatic surface interactions, and shape complementarity to bind to specific subcellular membranes.

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Animals Binding Sites Cell Membrane Humans Hydrophobic and Hydrophilic Interactions Lipid Metabolism Membrane Lipids Models, Molecular Protein Structure, Tertiary Protein Transport Signal Transduction Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Review

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James H Hurley. 2006-03-24. Membrane binding domains.. https://doi.org/10.1016/j.bbalip.2006.02.020

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