Programming CD8+ T cells for effective immunotherapy.

Christian S Hinrichs; Luca Gattinoni; Nicholas P Restifo

doi:10.1016/j.coi.2006.03.009

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Programming CD8+ T cells for effective immunotherapy.

Christian S Hinrichs·Luca Gattinoni·Nicholas P Restifo

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Abstract

The differentiation state of CD8+ T cells has emerged as a crucial determinant of their ability to respond to tumor and infection. Signals from T-cell receptors, co-stimulatory molecules and cytokine receptors direct the differentiation process. These signals 'program' sustained and heritable gene expression patterns that govern progressive differentiation and lineage commitment. The epigenetic mechanisms by which T cells are programmed are just beginning to be elucidated. Understanding the mechanisms that control CD8+ T-cell differentiation is important in the development of novel immunotherapy strategies.

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Animals CD8-Positive T-Lymphocytes Cell Differentiation Cytokines Humans Immunologic Memory Immunotherapy Models, Immunological Journal Article Research Support, N.I.H., Intramural Review

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Christian S Hinrichs, Luca Gattinoni, Nicholas P Restifo. 2006-04-17. Programming CD8+ T cells for effective immunotherapy.. https://doi.org/10.1016/j.coi.2006.03.009

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