Programmable implants--from pulsatile to controlled release.

C Guse; S Koennings; T Blunk; J Siepmann; A Goepferich

doi:10.1016/j.ijpharm.2005.12.051

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PubMed · 16551497

Programmable implants--from pulsatile to controlled release.

C Guse·S Koennings·T Blunk·J Siepmann·A Goepferich

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Abstract

The aim of this study was to develop programmable implants with a reproducible delayed onset of release followed by several weeks of controlled release. For this purpose, a drug-loaded core was embedded into a drug-free bulk-eroding poly(D,L lactic-co-glycolic acid) or poly(D,L lactic acid) mantle. The manufacturing procedure was established and optimized for three mantle materials, which showed delay times ranging from 7 to 83 days. Triglycerides with fatty acid chain lengths from C12 to C18 were investigated as core materials, producing release periods from 2 to 16 weeks. Concomitantly, applying a convolution/deconvolution model showed the possibility of theoretical prediction of the resulting release profiles.

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Arylsulfonates Cholesterol Drug Implants Kinetics Lactic Acid Models, Chemical Models, Theoretical Polyesters Polyglycolic Acid Polylactic Acid-Polyglycolic Acid Copolymer Polymers Solubility Technology, Pharmaceutical Triglycerides Journal Article Research Support, Non-U.S. Gov't

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C Guse, S Koennings, T Blunk, J Siepmann, A Goepferich. 2006-03-23. Programmable implants--from pulsatile to controlled release.. https://doi.org/10.1016/j.ijpharm.2005.12.051

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