PubMed · 16502550
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Dennis Miller, Jon Van Boening. 2006. Practical ethics. Bad behavior.. https://pubmed.ncbi.nlm.nih.gov/16502550/
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CD-1 mice were exposed to the organophosphate pesticide chlorpyrifos (CPF) both prenatally (gestational days 15-18; doses 0, 3 or 6 mg/kg) and postnatally (postnatal days 11-14, doses 0, 1 or 3 mg/kg). When four-month-olds, females underwent a social recognition test in which ultrasound vocalizations (USVs) and social investigation behavior emitted by a resident female in the presence of a female partner were measured during two subsequent 3 min sessions (interval between the two sessions 45 min). Throughout the social recognition test a marked increase in USVs was found in females prenatally treated with the highest CPF dose; USV increase was also paralleled by a selective increase in frequency and not in duration of social investigation. These results confirm that developmental exposure to CPF induces long-lasting alterations in the social behavior repertoire of the mouse, thus extending our previous observations on the effects of postnatal CPF on male agonistic behavior to the female sex. They also suggest that social recognition can be easily and rapidly assessed in the female mouse making it possible to evaluate, primarily by means of USV emission, even subtle alteration of social behavioral patterns dissociated from cognitive components of individual recognition.
Dominance status among female marmosets is reflected in agonistic behavior and ovarian function. Socially dominant females receive submissive behavior from subordinates, while exhibiting normal ovulatory function. Subordinate females, however, receive agonistic behavior from dominants, while exhibiting reduced or absent ovulatory function. Such disparity in female fertility is not absolute, and groups with two breeding females have been described. The data reported here were obtained from 8 female-female pairs of captive female marmosets, each housed with a single unrelated male. Pairs were classified into two groups: "uncontested" dominance (UD) and "contested" dominance (CD), with 4 pairs each. Dominant females in UD pairs showed significantly higher frequencies (4.1) of agonism (piloerection, attack and chasing) than their subordinates (0.36), and agonistic behaviors were overall more frequently displayed by CD than by UD pairs. Subordinates in CD pairs exhibited more agonistic behavior (2.9) than subordinates in UD pairs (0.36), which displayed significantly more submissive (6.97) behaviors than their dominants (0.35). The data suggest that there is more than one kind of dominance relationship between female common marmosets. Assessment of progesterone levels showed that while subordinates in UD pairs appeared to be anovulatory, the degree of ovulatory disruption in subordinates of CD pairs was more varied and less complete. We suggest that such variation in female-female social dominance relationships and the associated variation in the degree and reliability of fertility suppression may explain variations of the reproductive condition of free-living groups of common marmosets.
RATIONALE: Relapse to drug-seeking in abstinent heroin addicts and reinstatement in experimental animals are observed when exposed to drug-associated stimuli or cues, the drug itself, and stressful events. It has been shown that footshock-induced stress increases the rewarding effects of opiates, delays extinction, and induces the reinstatement of drug-seeking. However, the effects of social stress on the reinstatement of opiate-seeking after extinction has not been studied. OBJECTIVES: The role of physical (restraint and tail pinch) and social (social defeat) stressors on the reinstatement of morphine-induced conditioned place preference (CPP) was evaluated. METHODS: Adult male OF1 mice were conditioned with 10, 20, or 40 mg/kg of morphine or saline. Only morphine-conditioned animals acquired CPP. All mice underwent extinction sessions until the CPP was extinguished. Then, the effects of physical or social stress on the reinstatement of CPP were evaluated. Morphine- and saline-conditioned animals were exposed to the respective stressor or control stress condition immediately or 15 min before reinstatement tests. In experiment 1, animals underwent restraint for 15 min. In experiment 2, animals were exposed to tail pinch or placed in a cage without any manipulation for 15 min. In experiment 3, animals performed an agonistic encounter with an isolated or anosmic mouse or were placed in a cage without any social contact or manipulation. RESULTS: Restraint, tail pinch, and social defeat in an agonistic encounter with an isolated mouse produce the reinstatement of CPP in morphine-conditioned animals. CONCLUSIONS: These data demonstrate that social stress is as effective as physical stress in reinstating morphine-seeking.